The Immunizing Antigen of the Pneumococcus
نویسندگان
چکیده
Actively immunizing fractions of protein nature have been isolated from broth culture filtrates of Pneumococcus Type I by ultrafiltration, precipitation at a definite hydrion concentration, and the separation of a soluble picrate fraction. The method appears to be suitable for the initial purification of this antigen.
منابع مشابه
Studies on Pneumococcus Immunity
1. Active immunity against many lethal doses of Pneumococcus Types I, II, and III may be produced in mice by two or three subcutaneous injections of the homologous type of pneumococcus saline vaccine. 2. Mice may be actively immunized with the protein fraction obtained by treating pneumococci with anhydrous sodium sulfate or by solution of pneumococci in bile salts and precipitation with alcoho...
متن کاملImmunizing mice using different combination antigens of the PI-2a fimbria subunit of Streptococcus agalactiae
Background: Streptococcus agalactiae is the main causal pathogen of bovine mastitis (BM), causing considerable economic loss to the dairy industry worldwide. Vaccines against S. agalactiae play an important role in preventing disease. Aims: The aim of this study was to evaluate the immunoprotection of S. agalactiae pilus isla...
متن کاملThe Rôle of the Soluble Specific Substance in Oral Immunization against Pneumococcus Type I
1. Feeding the purified soluble specific substance of Type I pneumococcus protects rats against an intraperitoneal injection of the virulent organism. 2. This increased resistance resembles that obtained when the intact (dead) or dissolved bacteria are fed, as follows: (a) one feeding is sufficient, (b) the interval between the feeding and the appearance of the immunity is the same, (c) the dur...
متن کاملResistance to Pneumococcus Infection in Rabbits following Immunizing Injections of Heat-killed Pneumococcus Suspensions
The degree and duration of the active resistance against pneumococcus infection have been determined in rabbits which received intravenous injections of a heat-killed suspension of pneumococci of the three principal types. The resistance induced by the immunization procedure varied in degree and in duration with each type of Pneumococcus.
متن کاملتهیه و تخلیص آنتی‌بادی منوکلونال علیه آنتی‌ژن لیپوآرابینومان مانوزیله مایکوباکتریوم بویس
Background and Objective: Lipoarabinomannan mannesylated (ManLAm) is one of the lipoglycans which forms a considerable percent of Mycobacterium Bovis BCG’ cellular wall. Considering that generation of monoclonal antibody against ManLAM antigen has many applications, specifically, in order to design the diagnostic kit for rapid diagnosing of tuberculosis, so the main objective of this study wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 42 شماره
صفحات -
تاریخ انتشار 2003